Direct MOA receptors ephedrine interacts with?

Direct MOA receptors ephedrine interacts with?

• A. Alpha-1, Alpha-2, Beta-1
• B. Alpha-1, Alpha-2, Beta-2
• C. Alpha-1, Alpha-2, Beta-1, Beta-2
• D. Alpha-1 only

Answer: (C)

Ephedrine is a mixed-acting sympathomimetic, with direct agonist activity at all major adrenergic receptor subtypes. It directly stimulates alpha-1, alpha-2, beta-1, and beta-2 receptors. This direct receptor action contributes to vasoconstriction (alpha-1), increased heart rate and contractility (beta-1), and, via beta-2, potential bronchodilation and vasodilation in certain beds. In addition to this direct effect, it also increases norepinephrine release, giving it indirect sympathomimetic effects. So the best description of its direct MOA receptors is all four: alpha-1, alpha-2, beta-1, and beta-2.

Ephedrine is a mixed-acting sympathomimetic, with direct agonist activity at all major adrenergic receptor subtypes. It directly stimulates alpha-1, alpha-2, beta-1, and beta-2 receptors. This direct receptor action contributes to vasoconstriction (alpha-1), increased heart rate and contractility (beta-1), and, via beta-2, potential bronchodilation and vasodilation in certain beds. In addition to this direct effect, it also increases norepinephrine release, giving it indirect sympathomimetic effects. So the best description of its direct MOA receptors is all four: alpha-1, alpha-2, beta-1, and beta-2.